Leung Lab
Publications
20 papers since 2022, 13 as senior author.
2026
Rapp E., Pang J., Sati S., Huang J., Kim K., Ahart O., Zhao L., Myles T., Morser J., Rosenbach M., Leung L.L., and Leung T.H.
Therapeutic potential of blocking thrombin-activated osteopontin for non-infectious granulomatous diseases.
Nature Communications. In press.
Kersh A.E., Sati S., Ahart O., Jones P., Forrestel A., Wald J.W., and Leung T.H.
Rapid Single-cell Molecular Profiling Supports Tofacitinib Use in Steroid-dependent DRESS Myocarditis.
JAMA Dermatology. In press.
Ridky A., Zhou L., Rosenbach M., and Leung T.H.
Regulatory circuits that build and sustain non-infectious granulomas.
Genes & Development. Review. In press. [link]
Son A., Rapp E., Wiezorek A., Leung M.G., Banerjee R.R., and Leung T.H.
Cycling GLP-1 receptor agonist treatment induces therapeutic resistance and increased adiposity.
JCI Insight. 11(10):e205174 [link]
- Covered by: CBC, Yahoo! News, MSN
Zhou L., Kuehn H.S., Gager D., Silva A.A.G., Perelygina L.M., Hao L., Chen M.H., Niemela J.E., Stoddard J.L., Helm M., Wanat K., Sullivan K., Foulke G., Leung T.H., Rosenzweig S.D., Rosenbach M.
Fatal Systemic Granulomatous Disease Associated with Vaccine-Derived Rubella Virus in AIOLOS-Associated Immunodeficiency.
Journal of Clinical Immunology. 46(1):28. [link]
Foroohar T., Berk-Krauss J., Caplan A.S., Leung T.H., Barbieri J.S., Wanat K.A., Nelson C., Mangold A.R., English J.C. 3rd, Rosenbach M., Shields B.E., Damsky W.
Granuloma annulare: An updated review of epidemiology, molecular pathogenesis, and management.
Journal of the American Academy of Dermatology. Review. S0190-9622(26)02959-2. [link]
2025
Rapp E.*, Pang J.*, Saeednia B., Prouty S.M., Reilly C.A., and Leung T.H.
Carnosic acid in topical rosemary extract enhances skin repair via TRPA1 activation.
JCI Insight. e196267. [link]
Huang J.*, Sati S.*, Ahart O., Rapp-Reyes E., Zhou L., Micheletti R.G., James W.D., Rosenbach M., and Leung T.H. SAA1/FPR2 signaling between keratinocytes and neutrophils sustains chronic inflammation in Sweet syndrome.
Journal Clinical Investigation (JCI). 135(20):e193566. [link]
* These authors contributed equally to this work.
- Preview: Keratinocyte-neutrophil interactions revealed as targetable drivers of sustained inflammation in Sweet syndrome. J Clin Invest. 135(20):e198494. [link]
Zhou L. and Leung T.H.
Detection by single-cell RNA-sequencing of virally-mediated skin diseases.
JID Innovations. 100348. [link]
2024
Huang J.*, Sati S.*, Murphy C.*, Spencer C.A., Rapp E., Prouty S.M., Korte S., Ahart O., Sheng E., Jones P., Kersh A.E., Leung D., and Leung T.H.
Granulocyte-colony stimulating factor promotes scarless tissue regeneration.
Cell Reports. 43(10):114742. [link]
* These authors contributed equally to this work.
Kersh A., Sati S., Huang J., Murphy C., Ahart O., and Leung T.H.
Combination of CXCL9, CXCL10, and CCL19 secreted in lichen planus amplifies T lymphocyte recruitment to skin.
JCI Insight. e179899. [link]
Sati S., Huang J., Kersh A., Jones P., Ahart O., Murphy C., Prouty S., Hedberg M., Jain V., Gregory S.G., Leung D.H., Seykora J.T., Rosenbach M., and Leung T.H.
Recruitment of CXCR4+ type 1 innate lymphoid cells distinguish sarcoidosis from other skin granuloma diseases.
Journal Clinical Investigation (JCI). 134(17):e178711. [link]
- Preview: Type 1 innate lymphoid cells: a biomarker and therapeutic candidate in sarcoidosis.
J Clin Invest. 2024;134(17):e183708 [link]
Chen B., He B., Tucker A.M., Bilk I., Leung T.H., Schaer T.P., and Yang S.
An Environmentally Stable, Biocompatible, and Multilayered Wound Dressing Film with Reversible and Strong Adhesion.
Advanced Healthcare Materials. e2400827. [link]
2023
Bhattacharya S., Sheng E., Murphy C., Wei J., Kersh A., Nelson C.A., Bryer J.S., Ashchyan H.A., Steele K., Forrestel A., Seykora J.T., Micheletti R.G., James W.D., Rosenbach M., and Leung T.H.
Identification of a neutrophil-specific PIK3R1 mutation facilitates targeted treatment in a patient with Sweet syndrome.
Journal Clinical Investigation (JCI). 133(1):e162137. [link]
2022
Sati S., Jones P., Kim H., Zhou L.A., Rapp-Reyes E., and Leung T.H.
HiCuT: an efficient and low input method to identify protein-directed chromatin interactions.
PLOS Genetics. 18(3):e1010121. [link]
Brennan-Crispi D.M., Frankfurter M., Murphy C., Sheng E., Xu M., Morrisey E.E., Millar S.E.*, and Leung T.H.*
Fzd2 regulates murine hair follicle function and maintenance.
Journal of Investigative Dermatology. S0022-202X(22)00011-2. [link]
* These authors contributed equally to this work.
Leung T.H. and Cotsarelis G.
Cellular Memories—More than Skin Deep.
New England Journal of Medicine. 386:793-795. [link]
Veerabagu S.A., Trinklein R., Etzkorn J.R., Leung T.H., Miller C., Rosman I.S., and Friedman A.
The National Mentorship Match Algorithm: A New Approach to Filling Mentorship Gaps.
Journal of the American Academy of Dermatology. 88(4):922-924. [link]
Weiss E.H., Ko C.J., Leung T.H., Micheletti R.G., Mostaghimi A., Ramachandran S.M., Rosenbach M., Nelson C.A.
Neutrophilic Dermatoses: a Clinical Update.
Current Dermatology Reports. 11(2):89-102. [link]
Peraramelli S., Zhou Q., Zhou Q., Wanko B., Zhao L., Nishimura T., Leung T.H., Mizuno S., Ito M., Myles T., Stulnig T.M., Morser J., and Leung L.L.
Thrombin cleavage of osteopontin initiates osteopontin’s tumor-promoting activity.
Journal of Thrombosis and Haemostasis. 20(5):1256-1270, 2022. [link]
2021
Shields B.E., Perelygina L., Samimi S., Haun P., Leung T.H., Abernathy E., Chen M., Hao L., Icenogle J., Drolet B., Wilson B., Bryer J.S., England R., Blumberg E., Wanat K.A., Sullivan K., and Rosenbach M.
Granulomatous dermatitis associated with rubella virus infection in an adult with immunodeficiency.
JAMA Dermatology. 157(7):842-847, 2021. PMID: 34037685.
2020
Wei J.J., Kim H.S., Spencer C.A., Brennan-Crispi D., Zheng Y., Johnson N.M., Rosenbach M., Miller C., Leung D.H., Cotsarelis G., and Leung T.H.
Activation of TRPA1 Nociceptor Promotes Systemic Adult Mammalian Skin Regeneration.
Science Immunology. 5(50):eaba5683. [pdf]
- Covered by: Forbes
Prior to 2020
Wei J.J., Hayward E., Leung T.H., and Rosenbach M.
Unbearable wearables.
2019. Dermatology Online Journal. 25(12):13030.
Wei J.J., Kallenbach L.R., Kreider M., Leung T.H., and Rosenbach M.
Resolution of cutaneous sarcoidosis after Janus kinase inhibitor therapy for concomitant polycythemia vera.
2019. JAAD Case Reports. 5(4):360-361.
Spencer C.A. and Leung T.H.
Research Techniques Made Simple: Parabiosis to Elucidate Humoral Factors in Skin Biology.
2019. Journal of Investigative Dermatology. 139(6):1208-1213.
Nishiguchi M.A.*, Spencer C.A.*, Leung D.H., and Leung T.H.
Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration.
2018. Cell Reports. 24(13):3383-3392. [pdf]
* These authors contributed equally to this work.
- Covered by: Nature, The Conversation, ScienceDaily, LA Times, Genetic Engineering and Biotechnology News,
Penn Institute for Aging Newsletter
Siprashvili Z., Nguyen N.T., Gorell E.S., Loutit K., Khuu P., Furukawa L., Lorenz H.P., Leung T.H., Keene D.R., Riger K.E., Khavari P., Lane A.T., Tang J.Y., Marinkovich M.P.
Safety and Wound Outcomes Following Genetically Corrected Autologous Epidermal Grafts in Patients With Recessive Dystrophic Epidermolysis Bullosa.
2016. JAMA. 316(17):1808-1817.
Leung T.H., Snyder E.R., Liu Y., Wang J., and Kim S.K.
A cellular, molecular and pharmacological basis for appendage regeneration in mice.
2015. Genes & Development. 29(20):2097-107. PMID: 26494786.
- Research Highlight: How mice regrow ear tissue. Nature 527: 136-137.
- Covered by: PhillyVoice
- Thomas interviewed on National Radio: Sirius XM Radio Knowledge at Wharton
Gorrell E.S., Leung T.H., Khuu P., and Lane A.T.
Purified Type I Collagen Wound Matrix Improves Chronic Wound Healing in Patients with Recessive Dystrophic Epidermolysis Bullosa.
2015. Pediatric Dermatology. 32(2):220-5. PMID: 25557742.
Sebastiano V., Zhen H.H., Derafshi B.H., Bashkirova E., Melo S., Wang P., Leung T.L., Siprashvili Z., Tichy A., Li J., Ameen M., Hawkins J., Lee S., Li L., Schwertschkow A., Bauer G., Lisowski L., Kay M.A., Kim S.K., Lane A.T., Wernig M., and Oro A.E.
Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic epidermolysis bullosa.
2014. Science Translational Medicine. 26;6(264):264ra163. PMID: 25429056. [pdf]
Danial C., Tichy A.L., Tariq U., Swetman G.L., Khuu P., Leung T.H., Benjamin L., Teng J., Vasanawala S.S., and Lane A.T.
An open-label study to evaluate sildenafil for the treatment of lymphatic malformations.
2014. Journal of the American Academy of Dermatology. S0190-9622(14)01119-0. PMID: 24656411. [pdf]
Leung T.H., Zhang L., Wang J., Ning S., Knox S., and Kim S.K.
Hypochlorite ameliorates NF-κB-mediated skin diseases.
2013. Journal Clinical Investigation (JCI). 123(12):5361-70. PMID: 24231355. [pdf]
- Covered by: BBC News, Huffington Post, The Scientist, Reader's Digest, Allure, Daily Mail, Telegraph
Covert M.W.*, Leung T.H.*, Gaston J.E. and Baltimore D.
Achieving Stability of LPS-Induced NF-κB Activation.
2005. Science. 309(5742): 1854-7. PMID: 16166516. [pdf]
* These authors contributed equally to this work.
Leung T.H., Hoffmann A., and Baltimore D.
One nucleotide change in a kappa B site can determine cofactor specificity for NF-κB dimers.
2004. Cell. 118(4): 453-64. PMID: 15315758. [pdf]
- Preview: Little things that count in transcriptional regulation. Cell. 118:406-408
Hoffmann A., Leung T.H., and Baltimore D.
Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities.
2003. EMBO Journal. 22(20): 5530-9. PMID: 14532125. [pdf]
Last updated 10/31/26.