Leung Lab


Wei J.J., Kim H.S., Spencer C.A., Brennan-Crispi D., Zheng Y., Johnson N.M., Rosenbach M., Miller C., Leung, D.H., Cotsarelis G., and Leung T.H. (2020)

Activation of TRPA1 Nociceptor Promotes Systemic Adult Mammalian Skin Regeneration.

Science Immunology. 5(50):eaba5683. [pdf]

   - Covered by: Forbes

Wei J.J., Hayward E., Leung T.H., and Rosenbach M. (2019)

Unbearable wearables.

Dermatology Online Journal. 25(12):13030.

Wei J.J., Kallenbach L.R., Kreider M., Leung T.H., and Rosenbach M. (2019)

Resolution of cutaneous sarcoidosis after Janus kinase inhibitor therapy for concomitant polycythemia vera.

JAAD Case Reports. 5(4):360-361.

Spencer C.A. and Leung T.H. (2019)

Research Techniques Made Simple: Parabiosis to Elucidate Humoral Factors in Skin Biology

Journal of Investigative Dermatology. 139(6):1208-1213.

Nishiguchi M.A.*, Spencer C.A.*, Leung D.H., and Leung T.H. (2018)

Aging Suppresses Skin-Derived Circulating SDF1 to Promote Full-Thickness Tissue Regeneration

Cell Reports. 24(13):3383-3392. [pdf]

* These authors contributed equally to this work.

  - Covered by: Naturethe Conversation, ScienceDailyLA Times, Genetic Engineering and Biotechnology News,
                            Penn Institute for Aging Newsletter

Siprashvili Z., Nguyen N.T., Gorell E.S., Loutit K., Khuu P., Furukawa L., Lorenz H.P., Leung T.H., Keene D.R., Riger K.E., Khavari P., Lane A.T., Tang J.Y., Marinkovich M.P. (2016)

Safety and Wound Outcomes Following Genetically Corrected Autologous Epidermal Grafts in Patients With Recessive Dystrophic Epidermolysis Bullosa.

JAMA. 316(17):1808-1817.

Leung T.H., Snyder E.R., Liu Y., Wang J., and Kim S.K. (2015)  
A cellular, molecular and pharmacological basis for appendage regeneration in mice.
Genes and Development. 29(20):2097-107.  PMID: 26494786.

  - Research Highlight: How mice regrow ear tissue. Nature 527: 136-137.

  - Covered by: PhillyVoice

  - Thomas interviewed on National Radio: Sirius XM Radio Knowledge at Wharton

Gorrell E.S., Leung T.H., Khuu P., and Lane A.T.  (2015)
Purified Type I Collagen Wound Matrix Improves Chronic Wound Healing in Patients with Recessive Dystrophic Epidermolysis Bullosa.  
Pediatric Dermatology. 32(2):220-5.  PMID: 25557742.


Sebastiano V., Zhen H.H., Derafshi B.H., Bashkirova E., Melo S., Wang P., Leung T.L., Siprashvili Z., Tichy A., Li J., Ameen M., Hawkins J., Lee S., Li L., Schwertschkow A., Bauer G., Lisowski L., Kay M.A., Kim S.K., Lane A.T., Wernig M., and Oro A.E. (2014)  
Human COL7A1-corrected induced pluripotent stem cells for the treatment of recessive dystrophic
epidermolysis bullosa.

Science Translational Medicine.  26;6(264):264ra163.  PMID: 25429056. [pdf]


Danial C., Tichy A.L., Tariq U., Swetman G.L., Khuu P., Leung T.H., Benjamin L., Teng J., Vasanawala S.S., and Lane A.T. (2014)  
An open-label study to evaluate sildenafil for the treatment of lymphatic malformations.

Journal of the American Academy of Dermatology. S0190-9622(14)01119-0.  PMID: 24656411. [pdf]


Leung T.H., Zhang L., Wang J., Ning S., Knox S., and Kim S.K. (2013)
Hypochlorite ameliorates NF-κB-mediated skin diseases.

The Journal of Clinical Investigation. 123(12):5361-70.  PMID: 24231355. [pdf]

   - Covered by BBC news, Huffington Post, The Scientist, Reader's Digest, Allure, Daily MailTelegraph


Covert M.W.*, Leung T.H.*, Gaston J.E. and Baltimore D. (2005) 
Achieving Stability of LPS-Induced NF-κB Activation.

Science. 309(5742): 1854-7.  PMID: 16166516. [pdf]

* These authors contributed equally to this work.


Leung T.H., Hoffmann A., and Baltimore D. (2004) 

One nucleotide change in a kappa B site can determine cofactor specificity for NF-κB dimers.

Cell.  118(4): 453-64.  PMID: 15315758. [pdf]

   - Preview Article: Little things that count in transcriptional regulation.  Cell. 118:406-408


Hoffmann A., Leung T.H., and Baltimore D. (2003) 

Genetic analysis of NF-kappaB/Rel transcription factors defines functional specificities.

EMBO Journal.  22(20): 5530-9.  PMID: 14532125. [pdf]


Last updated 8/31/20.

Part 1: Introduction and Research -
00:00 / 00:00
Part 2: Business & Safety of Regenerative Medicine -
00:00 / 00:00
Part 3: Future of Regenerative Medicine -
00:00 / 00:00