Research Overview: Human Disease as Biological Discovery
We study human disease not only as pathology, but as a discovery system for revealing the organizing principles of mammalian immunity and repair. Our laboratory integrates human genetics, deeply phenotyped clinical cohorts, longitudinal sampling, single-cell and spatial omics, and mechanistic experimentation to move from human signal to causal mechanism.
Immune Cell Plasticity
How do tissue environments reprogram innate immune cells? We use neutrophilic inflammatory diseases to discover mechanisms of myeloid plasticity, tissue-instructed inflammation, and genetically specified immune dysfunction.
Granuloma Self-Organization
How do immune cells organize themselves into granulomas, and why do these structures persist? We use granulomatous skin diseases, including sarcoidosis, to uncover the signals that build and sustain granulomas and to find new targets for treatment.
Healing Skin Without a Scar
Why does adult skin heal by fibrosis in some contexts and regeneration in others? We study neuro-immune and systemic signaling circuits that control the switch between scarring and complete tissue repair.