Research Overview: Human Disease as Biological Discovery
We study human disease not only as pathology, but as a discovery system for revealing the organizing principles of mammalian immunity and repair. Our laboratory integrates human genetics, deeply phenotyped clinical cohorts, longitudinal sampling, single-cell and spatial omics, and mechanistic experimentation to move from human signal to causal mechanism.
We solve medical mysteries by turning unusual human diseases into experiments in biology.
Immune-Cell Plasticity
How do tissue environments reprogram innate immune cells? We use neutrophilic inflammatory diseases to discover mechanisms of myeloid plasticity, tissue-instructed inflammation, and genetically specified immune dysfunction.
Granuloma Self-Organization
How do immune cells assemble into organized inflammatory structures? We study granulomatous diseases to define the molecular signals and immune architectures that initiate and sustain granulomas.
Healing skin without a scar
Why does adult skin heal by fibrosis in some contexts and regeneration in others? We study neuro-immune and systemic signaling circuits that control the switch between scarring and complete tissue repair.