Research Overview: Human Disease as Biological Discovery
We study human disease not only as pathology, but as a discovery system for revealing the organizing principles of mammalian immunity and repair. Our laboratory integrates human genetics, deeply phenotyped clinical cohorts, longitudinal sampling, single-cell and spatial omics, and mechanistic experimentation to move from human signal to causal mechanism.
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We solve medical mysteries by turning unusual human diseases into experiments in biology.
Immune-Cell Plasticity
How do tissue environments reprogram innate immune cells? We use neutrophilic inflammatory diseases to discover mechanisms of myeloid plasticity, tissue-instructed inflammation, and genetically specified immune dysfunction.
Granuloma Self-Organization
How do immune cells assemble into organized inflammatory structures? We study granulomatous diseases to define the molecular signals and immune architectures that initiate and sustain granulomas.
Fibrosis versus Regeneration
Why does adult skin heal by fibrosis in some contexts and regeneration in others? We study neuro-immune and systemic signaling circuits that control the switch between scarring and complete tissue repair.