The Leung Lab uses diseased human tissue as a natural perturbation system to uncover fundamental mechanisms of immunity, inflammation, and repair. We combine human genetics, clinical cohorts, single-cell and spatial omics, and mechanistic experimentation to identify the biological signals that matter most. We use these signals to discover how immune cells acquire function, how granulomas self-organize, and how adult skin can move from scarring toward regeneration.​​

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     We are building a lab for scientists who want to discover fundamental biology from human disease – mechanisms that textbooks haven't written yet – and translate those findings into new ways to diagnose and treat patients.

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     Thomas Leung, MD, PhD, is the Herman Beerman Professor of Dermatology at the University of Pennsylvania. He received his MD and PhD through the UCLA–Caltech Medical Scientist Training Program, where he studied gene regulation in the laboratory of Nobel laureate David Baltimore, before completing dermatology residency and postdoctoral training at Stanford University.