The Leung Lab uses human diseased tissue as a natural perturbation system to uncover fundamental mechanisms of immunity, inflammation, and repair. We combine human genetics, deeply phenotyped clinical cohorts, longitudinal sampling, single-cell and spatial omics, and mechanistic experimentation to identify large-effect biological signals directly in human tissue. We use these signals to discover how immune cells acquire function, how granulomas self-organize, and how adult skin can be shifted from scarring toward regeneration.​​

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     We are building a lab for scientists who want to discover basic biology from human disease - uncovering mechanisms that textbooks haven't written yet - and translate those findings into new ways to diagnose, treat, and repair tissue.

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     Thomas Leung is a physician-scientist and the Herman Beerman II Endowed Professor of Dermatology. He completed his MD at UCLA and his PhD in Biology at Caltech under Nobel laureate David Baltimore, then trained in dermatology and did postdoctoral work at Stanford. He is an elected member of the American Society for Clinical Investigation and the Founding Director of Penn's 4D Center for Human Skin Biology.