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The Leung Lab is focused on how cellular interactions give rise to complex tissue behavior.
We use human disease as a natural experiment to uncover fundamental principles of immunity, inflammation, and tissue repair. By studying patients and developing experimental models, we seek to understand how immune cells acquire new functions, how granulomas organize themselves, and why injured skin scars rather than regenerates.
We are building a lab for scientists who want to discover fundamental biology from human disease – mechanisms that textbooks haven't written yet – and turn those findings into new ways to diagnose and treat patients. We combine human genetics, clinical cohorts, single-cell and spatial omics, and mechanistic experimentation to identify the biological signals that matter most.
Thomas Leung, MD, PhD, is the Herman Beerman Professor of Dermatology at the University of Pennsylvania. He received his MD and PhD through the UCLA–Caltech Medical Scientist Training Program, where he studied gene regulation in the laboratory of Nobel laureate David Baltimore, before completing dermatology residency and postdoctoral training at Stanford University.
Video abstracts about our latest papers
Latest news
Oct –– Emmanuel Rapp's paper on granuloma biology accepted at Nature Communications.
Oct –– Thomas elected into the American Dermatological Association.
Aug — Annika Ridky's review on granuloma biology published at Genes & Development.
Aug — Thomas Leung and Misha Rosenbach receive funding from Priovant Therapeutics to study human skin granulomas.
Jul — Kevin Kim receives an NIH F30 predoctoral fellowship to study granuloma biology.
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